https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29728 Wed 11 Apr 2018 10:02:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25346 Sat 24 Mar 2018 07:24:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31937 stroke may induce a neurodegenerative condition. Certainly, this is supported to some degree by the relatively high incidence of dementia after stroke. We begin this review by addressing the available research on human and rodent SND pathology after stroke. We next consider amyloid-β in the context of SND. We discuss what amyloid-β is, how is it made, and introduce some caveats on how amyloid-β measurements should be interpreted. In summary, we conclude that there is now robust pre-clinical evidence demonstrating the presence of amyloid disturbances at sites of SND after stroke. We find, however, that the human literature on the topic is more limited and further work is warranted. While the understanding of amyloid disturbances remains inconclusive in human studies, stroke clearly lead to the development of a neurodegenerative-like condition at the sites of SND, with prominent features such as death of neurons and gliosis]]> Mon 23 Sep 2019 13:48:18 AEST ]]>